Purpose of This Page

Trilogi Wellness content is grounded in established biology, biophysics, and systems science.

This page exist to:

• Provide transparent evidentiary support for concepts referenced across our educational materials

• Anchor clinical language in peer-reviewed research

• Allow readers, clinicians, and researchers to independently explore the science behind pattern, structure, signal, and regulation.

How to Use This Page

• References are organized by biological system or functional domain

• Posts and materials may reference one or more domains, but are not individually indexed

• Readers are encouraged to explore, cross-reference, and interpret the literature directly

Nervous System Regulation and Pattern Preservation

Core Nervous System & Patterning

• Sterling, P. (2012). Allostasis: A model of predictive regulation.Physiology & Behavior.

• Friston, K. (2010). The free-energy principle: a unified brain theory? Nature Reviews Neuroscience.

• Sporns, O. (2011). Networks of the Brain. MIT Press.

Emotion as Emergent Physiology (Not Storage)

• LeDoux, J. (2012). Rethinking the emotional brain. Neuron.

• Barrett, L.F. (2017). How Emotions Are Made. Houghton Mifflin Harcourt.

• Damasio, A. (1999). The Feeling of What Happens. Harcourt.

Autonomic Patterning & Setpoints

• Porges, S. (2011). The Polyvagal Theory. Norton.

• Thayer & Lane (2000). A model of neurovisceral integration.Biological Psychology.

Fascia, Structure & Adaptation

• Schleip et al. (2012). Fascial plasticity – a new neurobiological explanation. Journal of Bodywork & Movement Therapies.

• Findley & Schleip (2007). Fascia Research. Elsevier.

Cellular & Systems Memory

• Buzsáki, G. (2006). Rhythms of the Brain. Oxford University Press.

• Fields, R.D. (2008). White matter in learning and plasticity. Trends in Neurosciences.

Structured water & intracellular Architecture

Redox, Mitochondria & Energy Allocation

Circadian Coherence & Metabolic Patterning

Fascia, Mechanotransduction & Structural Signaling

Cell Danger Response & Chronic Patterns

Coherence, Prediction & Architectural Reorganization

Pollack GH. The Fouth Phase of Water: Beyond Solid, Liquid, and Vapor. Ebner and Sons; 2013.

Lang X, et al. Probing the structure of water in individual living cells. Nature Communications. 2024.
niversity Press.

• Fields, R.D. (2008). White matter in learning and plasticity. Trends in Neurosciences.

Wu R, et al. Redox signaling, mitochondrial metabolism, epigenetics and redox-active phytochemicals. Redox Biology. 2020.

Magnani ND, et al. Role of mitochondria in the redox signaling network and inflammation. Frontiers in Endocrinology. 2020.

Zha K, et al. Circadian rhythm: biological functions, diseases, and therapeutic opportunities. Signal Transduction and Targeted Therapy. 2025.

Konakchieva R, et al. Circadian clock deregulation and metabolic reprogramming. International Journal of Molecular Sciences. 2025.

Gromakovskis V, et al. Exploring fascia in myofascial pain syndrome: an integrative review. Frontiers in Physiology. 2025.

Wilke J, et al. Not merely a protective packing organ? A review of fascia and its force transmission capacity. Journal of Applied Physiology. 2018.

Naviaux RK. Metabolic features of the cell danger response. Mitochondrion. 2014.

Naviaux RK. Cell danger response biology: the new science that connects environmental health with mitochondria and chronic disease. Mitochondrion. 2020.

Friston K. The free-energy principle: a unified brain theory? Nature Reviews Neuroscience. 2010.

Strogatz SH. Sync: How Order Emerges from Chaos in the Universe, Nature, and Daily Life. Hyperion; 2003.

References are provided as a scientific resource library.

Inclusion does not imply endorsement of any single theory, but reflects converging evidence across systems biology, neuroscience, and physiology.

Redox & Mitochondrial Sleep Mechanisms

Richardson & Mailloux (2023) — Sleep is tied to dynamic redox and mitochondrial restoration, not just timing cues.

de Goede et al. (2018) — Mitochondrial respiration and morphology show circadian patterns regulated by molecular clocks.

Bothwell et al. (2018) — Neuronal redox oscillations influence excitability in circadian contexts.

Mir et al. (2025) — Reactive oxygen species act as bidirectional signals between cellular metabolic state and sleep regulation.

Circadian clock molecular networks and intracellular pathways — Fagiani et al. (2022)

Classical circadian pacemaker & sleep homeostasis interplay — Schwartz et al. (2019)